Composition

 100 g of ointment contains: Active substance: mupirocin - 2 g. Excipients: Macrogol 400 (polyethylene glycol 400), macrogol 4000 (polyethylene glycol 4000).

 Pharmachologic effect

Mupirocin is an antibiotic produced by the microorganism Pseudomonas fluorescens. Mupirocin inhibits bacterial cell protein synthesis by reversible binding to isoleucyl-transport RNA synthetase, which prevents the inclusion of isoleukin in the protein chains under construction. When used in minimal inhibitory concentrations, mupirocin has bacteriostatic, and at higher concentrations, bactericidal action. Due to a specific mechanism of action and a unique chemical structure, there is no cross-resistance with other antibiotics. With the correct application of mupirocin, the risk of the emergence of resistant strains of microorganisms is small. The spectrum of antibacterial activity in vitro: Gram-positive aerobes: Staphylococcus aureus (including strains resistant to methicillin and producing beta-lactamases), Staphylococcus epidermidis, Staphylococcus species, Coagulase-negative Staphylococcus; Gram-negative anaerobes: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis; Insensitive: Corynebacterium species, Enterobacteriaceae, Gram-negative non-fermenting sticks, Micrococcus.

Indications

 Primary and secondary infectious skin lesions caused by microorganisms susceptible to mupirocin, including: 1. Primary skin infections: -impetigo, -folliculitis, -furunculosis (including furuncles of external auditory canal and auricle), -ectiles; 2. Secondary infections: -infected eczema, -infected injuries (abrasions, insect bites, wounds, burns).