pharmachologic effect

Antibiotic of a group of aminoglycosides of a wide spectrum of action. Has a bactericidal effect, disrupting protein synthesis and permeability of the cytoplasmic membrane of bacteria.

Highly active against Pseudomonas aeruginosa.

Tobramycin is active against gram-negative bacteria: Escherichia coli, Proteus spp. (indole-positive and indole-negative strains), Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Shigella spp., Salmonella spp., Citrobacter spp., Haemophilus influenzae; Gram-positive bacteria: Staphylococcus spp. (including strains that produce penicillinase).

Maloactive against Streptococcus spp. (including Enterococcus spp.).

Indications

For systemic use: severe infectious and inflammatory diseases caused by tobramycin-sensitive pathogens (sepsis, meningitis, peritonitis, endocarditis, respiratory tract infections, skin and soft tissue infections, urinary tract infections, bone tissue infections).

For topical application: eye infections (as part of combination therapy).