pharmachologic effect

Antimicrobial agent group of fluoroquinolones with a wide spectrum of action. The bactericidal effect of ofloxacin is associated with the blockade of the DNA gyrase enzyme in bacterial cells.

Highly active against most gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Mycoplasma spp. as well as Chlamydia spp.

It is active against some gram-positive microorganisms (including Staphylococcus spp., Streptococcus spp., Especially beta-hemolytic streptococci).

To ofloxacin is moderately sensitive Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp.

Anaerobic bacteria are not sensitive to ofloxacin (except for Bacteroides ureolyticus).

Resistant to β-lactamase.

Indications of the drug

Infectious and inflammatory diseases caused by microorganisms sensitive to ofloxacin, including: diseases of the lower respiratory tract, ear, throat, nose, skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal cavity organs (except for bacterial enteritis ) and small pelvis, kidney and urinary tract infections, prostatitis, gonorrhea.