Pharmacological action

Antiemetic, helps to reduce nausea, hiccups; stimulates the peristalsis of the gastrointestinal tract. Antiemetic effect is due to blockade of dopamine D2 receptors and an increase in the threshold of chemoreceptors of the trigger zone, is a blocker of serotonin receptors. It is believed that metoclopramide inhibits the relaxation of the smooth muscle of the stomach caused by dopamine, thereby enhancing cholinergic reactions of the smooth muscles of the gastrointestinal tract. Promotes the acceleration of gastric emptying by preventing the relaxation of the body of the stomach and increasing the activity of the antrum of the stomach and upper parts of the small intestine. Reduces the reflux of the contents in the esophagus by increasing the pressure of the sphincter of the esophagus at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates the secretion of prolactin and causes a transient increase in the level of circulating aldosterone, which may be accompanied by a short-term fluid retention.

Indications

Vomiting, nausea, hiccough of different genesis. Atony and hypotension of the stomach and intestines (including postoperative); biliary dyskinesia; reflux esophagitis; flatulence; in the complex therapy of exacerbations of peptic ulcer of the stomach and duodenum; acceleration of peristalsis during radiocontrast studies of the gastrointestinal tract.