Dosage form
Tablets.
Composition
1 tab.

Metformin hydrochloride 500 mg
Pharmacological action
The oral hypoglycemic agent from the group of biguanides (dimethylbiguanide). The mechanism of action of Metformin is associated with its ability to suppress gluconeogenesis and the formation of free fatty acids and oxidation of fat. Metformin does not affect the amount of insulin in the blood, but alters the pharmacodynamics by reducing the ratio bound to free insulin and increase the ratio of insulin to proinsulin. An important link in the mechanism of action of Metformin is the stimulation of glucose uptake by muscle cells.

Metformin increases blood circulation in the liver and accelerates the process of conversion of glucose into glycogen. Lowers triglycerides, LDL, VLDL. Metformin improves fibrinolytic properties of blood due to the suppression of plasminogen activator inhibitor tissue-type

Contraindications
— diabetic ketoacidosis, diabetic precoma, coma;

— expressed violations kidney function;

— cardiac and respiratory failure, the acute phase of myocardial infarction, acute violation of cerebral circulation, dehydration, chronic alcoholism, and other conditions that can contribute to the development of lactate-acidosis;

— pregnancy and breastfeeding;

— major surgery or trauma, when is shown holding insulin;

— abnormal liver function;

acute alcohol poisoning;

— lactate acidosis ( including history);

— adherence to a reduced-calorie diet (less than 1000 kcal/);

— hypersensitivity to the drug.

The drug is contraindicated for at least 2 days before and for 2 days after the radioisotope and x-ray examination with the introduction of yodsoderzhaschih contrast agent.