pharmachologic effect

The blocker of histamine H1 receptors, a derivative of phthalazinone. It has a long anti-allergic and membrane-stabilizing effect, reduces capillary permeability and exudation, stabilizes the membrane of mast cells and prevents the release of biologically active substances (including histamine, serotonin, leukotrienes, platelet activating factor), causing bronchospasm and promoting early and late stage of allergic reactions and inflammation.

With local application, the systemic effect is negligible.

With intranasal administration reduces itching and stuffiness of the nose, sneezing and rhinorrhea. Relaxation of symptoms of allergic rhinitis is noted from 15 minutes after application and lasts up to 12 hours or more.

With prolonged use in high doses, there was no clinically significant effect of azelastine on the QT interval.

Indications

- treatment of seasonal and year-round allergic rhinitis (including hay fever) and rhinoconjunctivitis;

- treatment of symptoms of vasomotor (all-the-year non-allergic) rhinitis, such as nasal congestion, rhinorrhea, sneezing, postnatal syndrome