Dosage form

pills

Composition

naproxen 0.25 g; auxiliary substances:milk sugar, potato starch, polyvinylpyrrolidone type "Kollidon 25", magnesium stearinovokisly, tropeolin About

Pharmacological action

NSAIDs, a derivative naphtylpropionate acid. Anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action is associated with inhibition of the enzyme COX, which leads to the inhibition of synthesis of prostaglandins from arachidonic acid.

Inhibits platelet aggregation.

Reduces pain, including joint pain at rest and during movement, morning stiffness and swelling of the joints, helps to increase range of motion. Anti-inflammatory effect occurs by the end of the 1st week of treatment.

Testimony

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout; pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissue and musculoskeletal system. As an adjuvant in infectious-inflammatory diseases of ENT-organs, adnexitis, primary dysmenorrhea, headache and toothache.

Contraindications

Erosivno-azwenne shock syndrome in acute phase, "aspirin triad", a violation of hematopoiesis expressed by the human kidney (KK less 20 ml/min), expressed human liver, children's age up to 1 year, hypersensitivity to naproxen and other NSAIDs.

Drug interactions

While the use of antacids containing magnesium and aluminum, sodium bicarbonate decreases the absorption of naproxen.

While the use of indirect anticoagulants described cases slight enhance the action of anticoagulants.

At simultaneous application with amoxicillin describes a case of nephrotic syndrome; with acetylsalicylic acid may decrease the concentration of naproxen in plasma.

While the application may change the pharmacokinetic parameters of diazepam; with caffeine - increases the effect of naproxen; with lithium carbonate - may increase the concentration of lithium in the blood plasma; with methotrexate - may increase the toxicity of methotrexate.
There are reports of the development of myoclonus while the use of morphine.
While the use of prednisone may be a significant increase in concentrations of prednisolone in blood plasma; with probenecid - decrease the concentration of naproxen in plasma; salicyl