dosage form

The capsules are opaque, №3, with a white body and a blue cap; contents of capsules - crumbly or compressed white powder with a yellowish tinge.

Composition

ketoprofen 50 mg

Excipients: lactose, magnesium stearate, colloidal silicon dioxide.

The composition of the capsule shell: gelatin, titanium dioxide, dye blue patented "Patent blue V".

pharmachologic effect

NSAIDs, a propionic acid derivative. It has analgesic, anti-inflammatory and antipyretic effect. By inhibiting COX-1 and COX-2 and partly lipoxygenase, ketoprofen inhibits the synthesis of prostaglandins and bradykinin stabilizes lysosomal membranes.

Ketoprofen does not adversely affect the condition of the articular cartilage. 

testimony

- Symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (including rheumatoid arthritis, seronegative arthritis / ankylosing spondylitis, psoriatic arthritis, reactive arthritis /), osteoarthritis, gout, pseudogout);

- Pain (including headache, myalgia, neuralgiations, sciatica, post-traumatic and post-operative pain, pain in cancer, tuberculosis) .Protivopokazaniya- gastric ulcer and duodenal ulcer in the acute phase; - ulcerative colitis, Crohn's disease - hemophilia and other bleeding disorders - severe hepatic insufficiency - severe renal impairment; - uncompensated heart failure; - the postoperative period after coronary artery bypass surgery; - gastrointestinal, cerebrovascular and other bleeding or suspected bleeding - chronic indigestion - III of trimester of pregnancy - lactation (breastfeeding); - children up to age 15 - hypersensitivity to ketoprofen, aspirin or other NSAIDs; - indicate a history of asthma, urticaria and rhinitis caused by the intake of acetylsalicylic acid or other NPVS.Lekarstvennoe vzaimodeystvieKetoprofen reduce the effect of diuretics, antihypertensive sredstv.Usilivaet effect of oral hypoglycemic agents. when applied simultaneously with other NSAIDs, salicylates, corticosteroids and ethanol increases the risk of gastrointestinal krovotecheniy.Pri concomitant use with anticoagulants, thrombolytics, antiplatelet agents increases the risk of developing renal dysfunction krovotecheniy.Risk increases while taking diuretics or inhibitors APF.Pri concomitant use increases the concentration of cardiac glycosides, calcium channel blockers slow, drugs lithium, cyclosporine, metotreksata.Ketoprofen may reduce the effectiveness of mifepristone. NSAIDs should be started no earlier than 8-12 days after discontinuation mifepristona.Ketonal® can be combined with centrally acting analgesics. The solution may be mixed with morphine per vial.