Dosage form

Tablets

Composition

1 tablet contains: indomethacin - 25.0 mg

Pharmacological action

Indomethacin has anti-inflammatory, analgesic, antipyretic and anti-aggregating action. Suppresses the activity of proinflammatory factors reduces platelet aggregation. Inhibiting cyclooxygenase I and II , violates the metabolism of arachidonic acid, reduces the amount of prostaglandins (Pg) as in inflammation, and in healthy tissues, inhibits exudative and proliferative phases of inflammation. Eliminates or reduces pain syndrome and rheumatic rheumatic nature (includingwhen joint pain at rest and in motion, decrease morning stiffness and swelling of the joints, helps to increase range

movements; in inflammatory processes arising after operations and traumas; rapidly relieves both spontaneous pain and pain at movement, reduces inflammatory edema in the wound).

Testimony

Acute and chronic pain in inflammatory diseases of the musculoskeletal system: rheumatoid arthritis; juvenile chronic arthritis; chronic ankylosing spondylitis (Bechterew's disease); gouty arthritis; psoriatic arthritis; Reiter's disease; diseases of the periarticular tissue: tendinitis, bursitis, andobesity, tendovaginitis; injuries in athletes; slipped disc, neuritis, plexitis, radiculoneuritis. The medicine is intended for symptomatic therapy, reducing pain and the inflammation at the time of use, on disease progression is not affected.

Contraindications

Hypersensitivity to indomethacin or any of the excipients of the drug; anamnestic data about attack of bronchial mast, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs (complete or partial syndrome of intolerances acetylsalicylic acid – rhinosinusitis, urticaria, polyps are nasal mucosa, bronchial asthma); erosive-ulcerative changes of the gastric mucosa or 12 duodenal ulcer, active gastrointestinal bleeding; inflammatory bowel disease (ulcerative colitis, Crohn's disease);congenital heart disease (severe coarctation of the aorta, pulmonary artery atresia, severe tetralogy of Fallot); period after coronary artery bypass grafting; decompensated heart failure; renal failure (creatinine clearance (CC) less than 30 ml/min), a progressive kidney disease;
hepatic insufficiency or active liver disease; disorders of blood coagulation (including hemophilia, prolonged bleeding time, bleeding tendency); violation of hematopoiesis (leukopenia and anemia), confirmed hyperkalemia, hereditary lactose intolerance, lactase deficiency and glucose-galactose malabsorption, pregnancy and lactation; children's age (up to 14 years).