pharmachologic effect

An analgesic non-narcotic agent, a derivative of pyrazolone, nonselectively blocks COX and reduces the formation of prostaglandins from arachidonic acid.

It prevents painful extra and proprioceptive impulses along the Gaull and Burchard beams, raises the threshold of excitability of thalamic centers of pain sensitivity, increases heat transfer.

A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa. Has analgesic, antipyretic and some spasmolytic (with respect to the smooth muscles of the urinary and bile ducts) action.

Indications

- pain syndrome of different etiology (mild and moderate severity): incl. neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, trauma, burns, decompression sickness, shingles, orchitis, radiculitis, myositis, postoperative pain syndrome, headache, toothache, algodismenorea;

- febrile syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., posttransfusion complications).