pharmachologic effect
 Acriol Pro is a combined preparation that contains lidocaine and prilocaine, local anesthetics of the amide type. Anesthesia of the skin is caused by the penetration of lidocaine and prilocaine into the layers of the epidermis and dermis. The degree of anesthesia depends on the dose of the drug and the duration of the application.
Intact skin
 After applying the drug to the intact skin for 1-2 hours, the duration of anesthesia after the removal of the occlusive dressing is 2 hours. There were no differences in efficacy (including the time to achieve an analgesic effect) and safety when the drug was applied to intact skin in the elderly (65-96 years) and younger patients.
Due to the action of the drug on the surface vessels, temporary blanching or redness of the skin is possible. Similar reactions in patients with advanced neurodermatitis (atopic dermatitis) can occur more quickly, as early as 30-60 minutes after application, indicating a faster penetration of the cream through the skin.
 With puncture biopsy (diameter 4 mm), the use of Acryol Pro provides adequate anesthesia of the intact skin in 90% of patients 60 minutes after application of the drug when the needle is inserted to a depth of 2 mm and after 120 minutes when the needle is inserted at a depth of 3 mm. The effectiveness of the drug does not depend on the color or skin pigmentation (type of skin I-IV).
 When combined vaccines against such infections as measles, rubella, mumps, or intramuscular combined vaccines against diphtheria, whooping cough, tetanus, poliomyelitis and infection caused by Haemophilius influenzae type b, and when vaccinated against hepatitis B, the use of the drug did not affect the average antibody titre, the rate of appearance or disappearance of specific antibodies in the serum, or the number of patients who achieved a protective or positive titer of antibodies after immunization.
 Mucous membrane of genital organs
 Anesthesia of the mucous membrane of the genital organs is achieved faster in comparison with anesthesia of intact skin due to faster absorption of the drug.
 In women, 5-10 minutes after application of the drug to the mucous membrane of the genital organs, anesthesia is obtained sufficient for the relief of pain caused by the use of an argon laser; The duration of anesthesia is 15-20 minutes (taking into account individual characteristics from 5 to 45 minutes).
 Trophic ulcers of lower extremities
 After applying the drug in the treatment of trophic ulcers of the lower extremities, the duration of anesthesia is up to 4 hours. There was no adverse effect of the drug on the healing process of ulcers or against bacterial flora.

Indications
 In adults:
 - superficial anesthesia of the skin during injections (including vaccination), puncture and catheterization of vessels and superficial surgical interventions, including small cosmetic procedures and hair removal;
 - superficial anesthesia of trophic ulcers of the lower extremities during surgical treatment (mechanical cleaning), for example, to remove fibrin, pus and necrotic tissues;
 - superficial anesthesia of the mucous membrane of the genital organs before carrying out painful manipulations and for anesthesia before injections of local anesthetics.
 Children:
 - superficial anesthesia of the skin with injections (including vaccination), puncture and catheterization of vessels and surface surgical interventions (including when removing molluscum contagiosum).