pharmachologic effect

Combined drug with pronounced antihypoxic, nootropic and vasodilating action. The components mutually potentiate the decrease in the resistance of the blood vessels of the brain and contribute to the increase in blood flow in them.

Pyracetam is a nootropic agent. Activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission in the central nervous system and regional blood flow in the ischemic zone.

Cinnarizine is a selective blocker of slow calcium channels and an antagonist of histamine H1 receptors. It was found that it inhibits the entry of calcium ions into cells and reduces their content in the plasmolemma depot. Reduces the tone of the smooth muscle arterioles, reduces their response to biogenic vasoconstrictors (catecholamines, angiotensin and vasopressin). Has a vasodilating effect (especially with respect to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, increases the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood.

Indications

- Insufficiency of cerebral circulation (atherosclerosis of cerebral vessels, recovery period of ischemic and hemorrhagic strokes, after craniocerebral injuries, encephalopathy of various origins);

- intoxication;

- diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (memory, attention, mood);

- conditions after a craniocerebral injury;

- psychoorganic syndrome with symptoms of asthenia and adynamia predominating;

- asthenic syndrome of psychogenic genesis;

- Labyrinthopathy (dizziness, noise in the ears, nausea, vomiting, nystagmus);

- Meniere's syndrome;

- prevention of kinetosis;

- prevention of migraine;

- as part of complex therapy with low learning ability in children with psycho-organic syndrome.