Dosage form
The solution for the on/in and/m introduction colorless or slightly yellowish, transparent
Composition
etilmetilgidroksipiridina succinate 50 mg/ML

Auxiliary substances: sodium metabisulfite, water d/and
Pharmacological action
Mexidol® has antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effects, increases the body's resistance to stress. The drug increases organism resistance to the effects of major damaging factors, kislorodozawisimam pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, alcohol intoxication and antipsychotic drugs (neuroleptics)).

Mexidol® improves cerebral metabolism and blood flow to the brain, improves microcirculation and blood rheology, reduces platelet aggregation. Stabilizes the membrane structure of red blood cells (erythrocytes and platelets) in the blood. Has hypolipidemic effect, reduces total cholesterol and LDL. Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action of Mexidol® due to its antihypoxic, antioxidant and membrane-protective action. It inhibits the processes of lipid peroxidation, increases the activity of superoxide dismutase, increases the ratio of lipid-protein reduces the viscosity of the membrane increases its fluidity. Modulates the activity of membrane-bound enzymes (calziinezawisimoy phosphodiesterase, adenylyl cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine) that enhances their capability to bind to ligands, helps to preserve the structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission. Mexidol® increases the content of dopamine in the brain. Causes increased compensatory activity of aerobic glycolysis and reducing the degree of oppression oxidizing processes in the Krebs cycle in hypoxia with an increase in the content of ATP, creatine phosphate and activation energosintezirutuyu functions of mitochondria, stabilization of cell membranes.

Mexidol® normalizes metabolic processes in ishemizirovanna the myocardium reduces the zone of necrosis, restores and improves the electrical activity and contractility of myocardium and increases coronary blood flow in the ischemic zone, reduces the effects of reperfusion syndrome in acute coronary insufficiency. Increases antianginal activity nitropreparatov.

Mexidol® helps to preserve retinal ganglion cells and optic nerve fibers in progressive neuropathy, the causes of which are chronic ischemia and hypoxia. Improves the functional activity of the retina and optic nerve, increasing visual acuity.

Testimony
-acute disorders of cerebral circulation;

-traumatic brain injury, consequences of craniocerebral injuries;

-encephalopathy;

syndrome vegetative dystonia;

-mild cognitive disorder atherosclerotic Genesis;

-anxiety disorders with neurotic and neurosis-like States;

-acute myocardial infarction (from the first day) as part of complex therapy;

-primary open-angle glaucoma of various stages in the complex therapy;

-relief of withdrawal syndrome in alcoholism with the prevalence of neurosis and vegetative-vascular disorders;

-acute intoxication antipsychotic means;

-acute purulent-inflammatory processes of abdominal cavity (acute necrotizing pancreatitis, peritonitis) as part of combination therapy.
Contraindications
Acute liver and kidney failure, increased individual sensitivity to the drug. Well-controlled clinical studies safety of the drug Mexidol in children, during pregnancy and breastfeeding have not been conducted.
Drug interactions
In a joint application Mexidol® increases the effect of benzodiazepine derivatives anxiolytics, antiparkinsonian (levodopa) and an anticonvulsant (carbamazepine) funds.

Mexidol® reduces toxic effect of ethyl alcohol.