Pharmacological action

Anticoagulant of indirect action. It blocks in the liver the synthesis of vitamin K-dependent clotting factors, namely, II, VII, IX and X. The concentration of these components in the blood decreases, the process of blood clotting slows down.

The onset of anticoagulant action is observed 36-72 hours after the beginning of application of the drug with the development of maximum effect on 5-7 days from the beginning of application. After discontinuation of the drug, the restoration of vitamin K-dependent coagulation factors occurs within 4-5 days.

Indications

- treatment and prevention of thrombosis and embolism of blood vessels: acute and recurrent venous thrombosis, pulmonary embolism;

- secondary prevention of myocardial infarction and prevention of thromboembolic complications after myocardial infarction;

- prophylaxis of thromboembolic complications in patients with atrial fibrillation, lesions of the heart valves or with prosthetic heart valves;

- treatment and prevention of transient ischemic attacks and strokes, prevention of postoperative thrombosis.