Dosage form
Hard gelatin capsules, size №0, with an opaque orange cap and an opaque yellow body.
Composition
spironolactone 100 mg

Auxiliary substances: sodium lauryl sulfate, magnesium stearate, corn starch, lactose monohydrate.

The composition of the gelatin capsule: quinoline yellow (E104) C. I. 47005, titanium dioxide (E171) C. I. 77891, gelatin.
Pharmacological action
Potassium-sparing diuretic competitive antagonist of aldosterone.

In the distal nephron spironolactone prevents aldosterone delay of sodium and water and kaliwavodaschimi inhibits the effect of aldosterone, reduces the synthesis permeaz in aldosteronism plot of the collecting tubes and distal tubules. Communicating with the receptors of aldosterone increases the excretion of sodium ions, chlorine and water in the urine decreases the excretion of potassium ions and urea, reduces acidity of urine.

The hypotensive effect is due to a diuretic effect. The diuretic effect is manifested on day 2-5 of treatment.

Testimony
— essential hypertension (in combination therapy);

— otechny syndrome with chronic heart failure (can be used as monotherapy and in combination with standard therapy);

— a condition in which can occur secondary hyperaldosteronism, e.g. cirrhosis of the liver, accompanied by ascites and/or edema, nephrotic syndrome, and other conditions involving edema;

— hypokalemia/hypomagnesemia (as a subsidiary means for prophylaxis during treatment with diuretics and in case of impossibility of application of other methods of correction of potassium level);

— primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment;

— to establish the diagnosis of primary hyperaldosteronism.
Contraindications
— Addison's disease;

— hyperkalemia;

— hyponatremia;

— renal failure, severe (CC less than 10 ml/min);

— anuria;

— lactose intolerance, lactase deficiency, malabsorption syndrome glucose/galactose;

— pregnancy;

— lactation (breastfeeding);

— children up to age 3 years;

— hypersensitivity to the drug.

With caution should designate product if hypercalcemia, metabolic acidosis, AV-blockade (hyperkalemia contributes to its gain), diabetes (if confirmed or suspected chronic renal failure), diabetic nephropathy, surgery, taking drugs that cause gynecomastia, the holding of local and General anesthesia, menstrual irregularities, liver failure, liver cirrhosis, and in elderly patients.
Drug interactions
Verospiron reduces the effect of anticoagulants, anticoagulants (heparin, coumarin derivatives, indandiona) and toxicity of cardiac glycosides (because of the normalization of the potassium level in the blood prevents the development of toxicity).

Enhances metabolism Penisola.

Reduces the sensitivity of vessels to norepinephrine (requires compliance with caution during anesthesia).

Increases T1/2 of digoxin, so possible intoxication digoxin.

Strengthens toxic effect of lithium due to the decrease in its clearance.

Accelerates metabolism and excretion carbenoxolone.

Carbenoxolone promotes sodium retention spironolactone.

Corticosteroids and diuretics (derivatives benzothiazine, furosemide, ethacrynic acid) increase and accelerate the diuretic and natriuretic effects.

Enhances the effect of diuretic and antihypertensive drugs.

GCS enhance the diuretic and natriyureticeski effect with hypoalbuminemia and/or hyponatremia.