Pharmacological action

The xanthine derivative. Improves microcirculation in areas of impaired blood flow. Improves the rheological properties of blood (fluidity) due to the impact on the pathologically changed erythrocyte deformability, increases the elasticity of erythrocyte membranes, inhibits the aggregation of erythrocytes and platelets and reduces the increased viscosity of the blood. The mechanism of action of the drug is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in the cells of the smooth muscles of the vessels and in the shaped elements of the blood. Pentoxifylline inhibits the aggregation of platelets and erythrocytes, reduces the level of fibrinogen in the blood plasma and enhances fibrinolysis, which leads to a decrease in blood viscosity and improvement of its rheological properties. Improves the supply of oxygen to tissues in areas of the circulatory system (including in the extremities, the central nervous system, and to a lesser extent - in the kidneys). In the occlusive lesion of peripheral arteries (intermittent claudication) leads to an increase in walking distance, elimination of night cramps of gastrocnemius muscles, and reduction of pain at rest. When the cerebral circulation is disturbed, it improves the symptoms. Has a weak myotropic vasodilating effect, somewhat reduces the OPSS and slightly dilates the coronary vessels.

Indications

- violations of peripheral circulation against atherosclerotic, diabetic and inflammatory processes (including intermittent claudication caused by atherosclerosis, obliterating endarteritis, diabetic angiopathy);

- acute and chronic disorders of cerebral circulation of ischemic genesis;

- symptomatic treatment of the consequences of cerebrovascular accident of atherosclerotic origin (attention deficit disorder, dizziness, memory impairment);

- Atherosclerotic and discirculatory encephalopathy, angioedema (paresthesia, Raynaud's disease);

- trophic tissue disorders due to violation of arterial or venous microcirculation (postthrombophlebitic syndrome, trophic ulcers, gangrene, frostbites);

- impaired blood circulation of the eye (acute and chronic circulatory insufficiency in the mesh or choroid of the eye);

- Dysfunction of the middle ear of vascular genesis, accompanied by deafness.