pharmachologic effect

Selective beta-1-adrenoblocker, without its own sympathomimetic activity, does not have a membrane-stabilizing action.

Has only a slight affinity for the β2-adrenoreceptors of the smooth muscles of the bronchi and vessels, as well as to β2-adrenoreceptors involved in the regulation of metabolism. Therefore, bisoprolol as a whole does not affect the resistance of the respiratory tract and the metabolic processes in which β2-adrenergic receptors are involved.

The selective effect of the drug on β1-adrenergic receptors persists beyond the therapeutic range.

Bisoprolol does not have a pronounced negative inotropic effect.

The maximum effect of the drug is achieved 3-4 hours after ingestion. Even with the appointment of bisoprolol 1 time / day, its therapeutic effect persists for 24 hours due to the fact that its T1 / 2 from the blood plasma is 10-12 hours. As a rule, the maximum reduction in BP is achieved 2 weeks after the start of treatment.

Bisoprolol reduces the activity of the sympathoadrenal system by blocking the β1-adrenergic receptors of the heart.

With a single oral intake in patients with IHD without signs of chronic heart failure, bisoprolol reduces heart rate, reduces stroke volume of the heart and, as a result, reduces the ejection fraction and myocardial oxygen demand. With prolonged therapy, the initially increased OPSS decreases. Reduction of renin activity in blood plasma is considered as one of the components of antihypertensive action of beta-blockers.

Indications

- arterial hypertension;

- IHD: stable angina;

Chronic heart failure.