pharmachologic effect

An antiviral agent. It is a prodrug, the active metabolite (oseltamivir carboxylate) of which selectively suppresses influenza A and B neuraminidase. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between the terminal sialic acid and sugar, thereby promoting the spread of the virus in the airways (the virions exit from the infected cell and penetration into the cells of the epithelium of the respiratory tract, preventing inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside the cells and competitively suppresses the neuraminidase of the virus. It inhibits the growth of the influenza virus in vitro and suppresses the replication of the virus and its pathogenicity in vivo. Reduces the allocation of influenza A and B virus from the body.

Does not affect the production of antibodies in response to the introduction of an inactivated influenza vaccine.

The frequency of resistance of clinical isolates of the virus is 2%.

Indications

Flu types A and B.