Pharmacological action

NSAID, an indoleacetic acid derivative. Has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is associated with inhibition of the enzyme COX, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.

Suppresses the aggregation of platelets.

When administered orally and parenterally contributes to the weakening of the pain syndrome, especially joint pain at rest and during movement, a decrease in morning stiffness and swelling of the joints, an increase in the volume of movements. The anti-inflammatory effect develops by the end of the first week of treatment.

With topical application removes pain, reduces swelling and erythema.

With external application, in addition, helps reduce morning stiffness, increase the volume of movements.

Indications

For systemic use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of the soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea. As an auxiliary agent for infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

For topical application: prevention of inflammation in surgical interventions for cataracts and in the anterior segment of the eye, inhibition of miosis during surgery.

For external use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of the soft tissues and joints.