Acyclovir analogue with the same active substance Zovirax

pharmachologic effect

The antiviral drug is a synthetic analogue of the acyclic purine nucleoside, which has a highly selective effect on herpes viruses. In virus infected cells by the viral thymidine kinase phosphorylation occurs and further sequential transformation of acyclovir in mono-, di- and triphosphate. Acyclovirtriphosphate is inserted into the viral DNA chain and blocks its synthesis by competitive inhibition of the viral DNA polymerase.

In vitro, acyclovir is effective against herpes simplex virus - Herpes simplex 1 and 2 types; against the Varicella zoster virus, which causes varicella and herpes zoster; higher concentrations are required to inhibit the Epstein-Barr virus. Moderately active against cytomegalovirus.

In vivo, acyclovir is therapeutically and prophylactically effective, especially in viral infections caused by the Herpes simplex virus type 1 and type 2. Prevents new elements disease, reduces the likelihood of cutaneous dissemination and visceral complications accelerates education crusts, reduces pain in the acute phase of herpes zoster.

Indications

- treatment of infections of the skin and mucous membranes caused by viruses Herpes simplex 1 and 2 types, both primary and secondary, including genital herpes;

- prevention of exacerbations of recurrent infections caused by Herpes simplex 1 and 2 types, in patients with normal immune status;

- Prevention of primary and recurrent infections caused by Herpes simplex viruses 1 and 2 types, in patients with immunodeficiency;

- in the complex therapy of patients with severe immunodeficiency: in HIV infection (stage AIDS, early clinical manifestations and a developed clinical picture) and in patients who underwent bone marrow transplantation;

- treatment of primary and recurrent infections caused by the Varicella zoster virus (chickenpox, as well as herpes zoster)