pharmachologic effect

Antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of ornidazole reacts with DNA cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolitica, Lamblia spp., And obligate anaerobes Bacteroides spp. (including Bacteroides fraglis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P.bivia, P. buccae, P.disiens), and some gram-positive microorganisms (Eubacterium spp ., Clostridium). Orniferous microorganisms are not sensitive to ornidazole.

Indications

- Trichomoniasis;

- Amoebiasis: amoebic dysentery, extra-intestinal amebiasis (including amoebic liver abscess);

- giardiasis;

- prevention of infections caused by anaerobic bacteria, in operations on the colon and in gynecology.