Dosage form

Ointment for external application 1%

Composition

clotrimazole 10mg; 

Auxiliary substances: castor oil, water soluble cellulose, monoglycerides dist., propylene glycol, emulsifier, nipagin, succinic-TA

Pharmacological action

Clotrimazole is an antifungal means broad-spectrum for local use. Antimycotic effect of active substance (a derivative of imidazole) is associated with impaired synthesis of ergosterol, part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis. In small concentrations it acts fungistaticeski, and large - fungicidal, and not only on proliferiruyuchei cells.At fungicidal concentrations, interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. Effective against dermatophytes, yeast and molds, as well as multi-colored lichen of causative agent of Pityriasis versicolor (Malazessia furfur) and the causative agent of erythrasma.Has antimicrobial action against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), and against Trichomonas vaginalis.

Testimony

--fungal skin diseases, fungal infections of the skin folds of the feet;

-pityriasis versicolor, erythrasma superficial candidiasis, caused by dermatophytes, yeast (including the genus Candida), molds and other fungi and pathogens that are sensitive to clotrimazole;

-mycoses complicated by secondary pyoderma.

Contraindications

Hypersensitivity to clotrimazole or auxiliary substances, the first trimester of pregnancy.

With care - lactation.