pharmachologic effect

Antimicrobial agent of the group of fluoroquinolones of wide spectrum of action. The bactericidal effect of ofloxacin is associated with the blockade of the DNA-gyrase enzyme in bacterial cells.

Highly active against most Gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Mycoplasma spp., Legionella pneumophila, Acinetobacter spp., as well as Chlamydia spp.

It is active against some Gram-positive microorganisms (including Staphylococcus spp., Streptococcus spp., Especially beta-hemolytic streptococci).

To ofloxacin moderately sensitive Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp.

Ofloxacin is not sensitive to anaerobic bacteria (except Bacteroides ureolyticus).

Resistant to the action of β-lactamases.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to ofloxacin, including: diseases of the lower respiratory tract, ear, throat, nose, skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal cavity (with the exception of bacterial enteritis ) and small pelvis, infection of the kidneys and urinary tract, prostatitis, gonorrhea.