pharmachologic effect

Antimicrobial synthetic agent of the group of fluoroquinolones of wide spectrum of action. Has a bactericidal effect. Suppressing the DNA-gyrase, violates the process of supercoiling of DNA.

Highly active against most Gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

It is active against some gram-positive bacteria (including Staphylococcus aureus).

To norfloxacin resistant anaerobic bacteria are resistant, low-sensitivity Enterococcus spp. and Acinetobacter spp.

Resistant to the action of β-lactamases.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration: diseases of the urinary tract, prostate, GIT, gonorrhea, prevention of recurrence of urinary tract infections, bacterial infections in patients with granulocytopenia, traveler's diarrhea.

For topical application: conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcer, blepharitis, blepharoconjunctivitis, acute inflammation of the meibomian glands and dacryocystitis, prophylaxis of eye infections after removal of foreign bodies from the cornea or conjunctiva, after damaging chemicals, before and after surgical procedures on the eye; otitis externa, acute otitis media, chronic otitis media, prevention of infectious complications during surgical interventions on the hearing organ.