Dosage form
Pills
Composition
metronidazole 250mg;

Auxiliary substances: corn starch, povidone, magnesium stearate
Pharmacological action
Antiprotozoal and antimicrobial preparation, derivative of 5-nitroimidazole. The mechanism of action consists in biochemical restoration of 5-nitrogroup by intracellular transport proteins of anaerobic microorganisms and protozoa, restored 5-nitro group interacts with deoxyribonucleic acid (DNA) of cells of microorganisms by inhibiting the synthesis of their nucleic acids, leading to death of bacteria.

Active against Trihomonas vaginalis, Entamoeba histolica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp. Prevotella (P. bivia, P. buccae, P. disiens) and some gram-positive bacteria (Eubacterium spp., Clostridium spp. Peptococcus spp., Peptostreptococcus spp.). Minimum overwhelming concentration for these strains is 0.125-6.25 mcg/ml.

In combination with amoxicillin is active against Helicobacter pylori (Amoxicillin suppresses development of resistance to metronidazole).

Testimony
Protozoal infection: extraintestinal amoebiasis including amoebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis, giardiazis, balantidiasis, lamblias, cutaneous leishmaniasis, Trichomonas vaginitis, Trichomonas urethritis.

Infections caused by Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus): infections of bones and joints, infections of the Central nervous system (CNS), including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema, lung abscess.

Infections caused by species Bacteroides, including the B. fragilis group, Clostridium species: sepsis.

Pseudomembranous colitis (associated with use of antibiotics).

Gastritis or ulcer dvenadtsatiperstnoi intestine, associated with Helicobacter pylori, alcoholism.

Prevention of postoperative complications (especially intervention colon, kolorektalnah region, appendectomy, gynecological operations).

Radiation therapy of patients with tumors - as a radiosensitizing
Contraindications
Hypersensitivity, leukopenia (including history), organic lesions of the Central nervous system (including epilepsy), liver failure (in the case of appointment of high doses), pregnancy (I trimester), lactation.

Precautions - pregnancy (II and III trimenon), kidney/liver failure.