pharmachologic effect

Antibiotic group macrolides. Has a bacteriostatic effect. However, in high doses against sensitive microorganisms has a bactericidal effect. Erythromycin reversibly binds to the ribosomes of bacteria, thereby suppressing protein synthesis.

It is active against gram-positive bacteria: Staphylococcus spp. (strains producing and not producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae); Gram-negative bacteria: Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., Bacillus anthracis, Corynebacterium diphtheriae; anaerobic bacteria: Clostridium spp.

Erythromycin is also active against Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp.

To erythromycin, gram-negative rods are stable, incl. Escherichia coli, Pseudomonas aeruginosa, Shigella spp., Salmonella spp.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to erythromycin, incl. diphtheria, whooping cough, trachoma, brucellosis, legionnaires disease, tonsillitis, scarlet fever, otitis, sinusitis, cholecystitis, pneumonia, gonorrhea, syphilis. Treatment of infectious and inflammatory diseases caused by pathogens (in particular, staphylococci), resistant to penicillin, tetracyclines, chloramphenicol, streptomycin.

For external use: youthful acne.

For topical application: infectious and inflammatory eye diseases.