Dosage form

Tablets, film-coated

Composition

1 tab. 

ciprofloxacin 500 mg

Pharmacological action

An antimicrobial agent of broad-spectrum fluoroquinolone. Has a bactericidal effect. Inhibits DNA-girazu and inhibits the synthesis of bacterial DNA.

Is highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.

It is active against Staphylococcus spp. (including strains producing and not producing penicillinase, methicillin-resistant strains), some strains of Enterococcus spp. Campylobacter spp. Legionella spp. Mycoplasma spp. Chlamydia spp., Mycobacterium spp.

Ciprofloxacin is active against bacteria producing beta-lactamases.

To ciprofloxacin resistant Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Activity against Treponema pallidum has been insufficiently studied.

Testimony

Infectious-inflammatory diseases caused by susceptible to ciprofloxacin microorganisms, including diseases of the respiratory tract, abdominal cavity and small pelvis organs, bones, joints, skin, septicemia; severe infections of ENT-organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.

For local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meibomitis. Infections of the eye after injury or contact with foreign bodies Preoperative prophylaxis in ophthalmic surgery.

Contraindications

Pregnancy, lactation (breastfeeding), childhood and adolescence to 15 years, increased sensitivity to ciprofloxacin and other drugs hinolonovogo series.

Drug interactions

With simultaneous use of ciprofloxacin with DDI absorption of ciprofloxacin is reduced due to the formation of complexons of ciprofloxacin with didanosine contained in the aluminum and magnesium buffers.

While the use of warfarin increases the risk of bleeding.

With simultaneous use of ciprofloxacin and theophylline may increase the concentration of theophylline in blood plasma, increase in T1/2 of theophylline, leading to increased risk of developing toxic effects associated with theophylline.

Concomitant use of antacids as well as drugs, containing ions aluminium, zinc, iron or magnesium may decrease the absorption of ciprofloxacin, so the interval between administration of these drugs should be at least 4 hours.