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Listed in Category: Antibacterial medication

Amoxicillin 250 Mg 16 Capsules

Availability: In Stock



Active ingredients: Amoxicillin
Manufacturer: Hemofarm Group AD
Country of Origin: Serbia
General description: Antibiotic penicillin group of broad-spectrum.

Dosage form

Gelatin capsules, size No. 2, with a cap of dark green and white with a yellowish sheen color; the contents of capsules - granular powder from white to light yellow color.


amoxicillin (trihydrate)250 mg
Excipients: magnesium stearate, cellulose microcrystalline PH 102.
The composition of the capsule shell: titanium dioxide (E171), quinoline yellow dye (E104), dye azorubin (Е122), dye patented blue V (E131), brilliant black dye (Е151), gelatin

Pharmacological action

Amoxicillin - broad-spectrum antibiotic of group semisynthetic penicillins, bactericidal effect, is Destroyed by beta-lactamase. Active against gram-positive and gram-negative microorganisms, such as Strеptococcus pyogenes, pneumoniae Strеptococcus, Clostriduim tetani, C. Welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus, Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active against: Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae.Not active against organisms producing beta-lactamase, Pseudomonas, indole-positive Proteus, Serratia, Enterobacter.
After intake of amoxicillin is absorbed rapidly and almost completely (93%), acid-resistant. Eating virtually no effect on drug absorption. The maximum concentration of active substance in plasma observed after 1-2 hours.
About 17% of amoxicillin is bound to plasma proteins. Amoxicillin penetrates mucous membranes, bone tissue and the intraocular fluid, sputum in therapeutically effective concentrations. Amoxicillin concentration in the bile exceeds its concentration in plasma in 2-4 times. In the amniotic fluid and in umbilical cord vessels of the amoxicillin concentration is 25-30% from its level in the blood plasma of a pregnant woman. Amoxicillin does not penetrate the BBB;however, when inflammation of the meninges (e.g. meningitis) concentration in cerebrospinal fluid is about 20% of the concentration in the blood plasma.
Amoxicillin partly metabolised, the majority of its metabolites are inactive against microorganisms.
Amoxicillin is eliminated primarily by the kidneys, about 80% by kanalzeva excretion, 20% - by clubockova filtering.
In the absence of renal dysfunction the half-life of amoxicillin is 1-1.5 h. in preterm, newborns and children under the age of 6 months. - 3-4 hours When impaired renal function (creatinine clearance equal or less than 15 ml/min) the elimination half-life of amoxicillin is increased and reaches with anuria 8.5 h



Bacterial infections caused by sensitive microflora: 
infection of the respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media; bronchitis, pneumonia)
— infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis);
infection of the gastrointestinal tract (peritonitis, enterocolitis, typhoid, cholangitis, cholecystitis);
— infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis); leptospirosis;
— Listeria;
— Lyme disease (borreliosis);
— salmonellosis;
— salmonellonoyestvo;
— endocarditis (prevention);
— sepsis.


— allergic diathesis;
— bronchial asthma;
— hay fever;
— infectious mononucleosis;
— lymphocytic leukemia;
— liver failure;
— diseases of the gastrointestinal tract in the anamnesis (especially colitis associated with antibiotic use);
— lactation;
— hypersensitivity (W. to other penicillins, cephalosporins, carbapenems).
Caution - pregnancy, renal failure, bleeding history

Drug interactions

The probenecid, phenylbutazone, acceptbutton, to a lesser extent acetylsalicylic acid and sulfinpirazon inhibit tubular secretion of penicillin drugs, leading to increased half-life and concentration of amoxicillin in blood plasma.
Amoxicillin acts only on proliferating microorganisms, so it should not be administered concurrently with antimicrobials acting bacteriostatic.
In the presence of positive tests for sensitivity of the pathogen amoxicillin may be used in combination with other bactericidal antibiotics


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