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Listed in Category: Hormonal medication

Androcur 10 mg 15 tablets

Availability: In Stock

$79.00

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Active ingredients: Cyproterone
Manufacturer: Bayer
Country of origin: Germany
General description: The antiandrogen
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Dosage form
pills


Pharmacological action
Androkur is a hormonal anti-androgenic drug.

 

The active substance of Androkur drug reduces the influence of male sex hormones (androgens) that are produced in small amounts in the female body. Competitive displacement of androgens in target organs leads to relief of symptoms in androgen-dependent conditions such as abnormal growth of hair in hirsutism, androgenetic alopecia and increased function of the sebaceous glands in acne and seborrhea. The decrease in the concentration of androgens due to antigonadotropnym action of cyproterone provides additional therapeutic effect. These changes are reversible after discontinuation of the drug. In the combined reception with Diane®-35 is the suppression of ovarian function.

 

Systemic toxicity

Available results of preclinical studies of toxicity by repeated application of the drug does not assume any specific risk for humans.

Embryotoxicity/teratogenicity

Study of embryotoxicity showed no teratogenic effect after the use of the drug during the period of organogenesis before the development of the external genitalia. Receiving cyproterone at high doses during the hormone-sensitive differentiation phase of the genital organs led to the appearance of the signs of the feminization of male fetuses. Newborn boys whose mothers had received cyproterone during pregnancy did not reveal any signs of feminization. Use of the preparation Androkur® during pregnancy is contraindicated.

Genotoxicity and Carcinogenicity

During the first series of preclinical studies the genotoxicity of cyproterone were obtained negative results. However, the ability of cyproterone to form compounds with DNA, including increased activity of DNA repair in liver cells of different species of animals and in freshly prepared culture of human hepatocytes.

 

Effects of treatment with cyproterone in vivo in female rats was more frequent incidence of focal, possibly precancerous, lesions in the liver with altered enzyme content of the cells and an increase in the frequency of mutations in bacterial gene in transgenic rats.

Clinical experience and carefully conducted epidemiological studies do not confirm the increased incidence of liver tumors in humans. Rodent studies also give no indication of specific oncogenic potential of cyproterone. However, be aware that sex hormones can induce growth of certain hormone dependent tissues and tumors

Testimony
Manifestations of of moderate severity androgenization in women, such as:

• hirsutism is moderate;

• androgenic alopecia moderate;

• severe and moderate forms of acne, accompanied by inflammation, nodule formation or risk of scarring, and oily.

The drug is used in combination therapy with the drug Diane®-35 in cases where it is not observed clinical improvement in response to different treatment was not achieved satisfactory results when using only drug Diane®-35.
Contraindications
Pregnancy and breastfeeding, liver disease, syndrome, Dubin-Johnson, Rotor syndrome, liver tumors (including in history), idiopathic jaundice or persistent itching during a previous pregnancy, herpes pregnant women in history, cachexia, severe chronic depression, meningioma (incl. in history), thrombosis (arterial and venous) and thromboembolism in the present or in history (including thrombosis, deep vein thrombophlebitis, pulmonary embolism, myocardial infarction, stroke, cerebrovascular disorders), severe diabetes mellitus, diabetic angiopathy, sickle cell anemia, lactase deficiency, lactose intolerance, glucose-galactose malabsorption revealed hormone-dependent cancers (including of the genitals or mammary glands) or suspicion on them, vaginal bleeding of unknown etiology hypersensitivity to any component of the preparation Androkur®, adolescence
Drug interactions
On a background of reception of preparation Androkur® may change the need for oral hypoglycemic agents or insulin.

Studies on drug interactions have not been undertaken, but as the preparation Androkur® is metabolized by CYP3A4, it is expected that ketoconazole, Itraconazole, clotrimazole, ritonavir and other strong inhibitors of CYP3A4 would be to inhibit the metabolism of cyproterone. And, therefore, inducers of CYP3A4, such as rifampicin, phenytoin and products containing St. John's wort can reduce the concentration of cyproterone in the blood plasma.

In chronic alcoholism on the background of the use of high doses of the drug may decrease (weakening) of the effect of therapy in the treatment of increased libido in men. Guess it could be related to the induction by alcohol of enzymes involved in the metabolism and excretion of cyproterone.

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